The ILSB-MSL instrument inventory currently includes, Thermo Orbitrap Fusion Tribrid MS coupled UHPLC, Waters Synapt G2 equipped with capabilities for surface-induced dissociation (SID), Agilent 6560 ion mobility-Q-ToF extended mass range (20 kDa m/z) MS equipped with UHPLC, Agilent 6545 Q-TOF with extended mass range (30 kDa) equipped with UHPLC, a one-of-a-kind Fourier-transform IMS-Orbitrap MS (Thermo Exactive EMR extend mass range). These advanced MS instrumentation and highly skilled staff in the ILSB-MSL offers TAMU scientists access to more advanced and diverse mass spectrometry research capabilities. The research capabilities of the ILSB-MSL are further augmented by the staff and instrumentation in the NIH P41 "Resource in Native MS Guided Structural Biology", which is also located in the ILSB.
An Obitrap mass spectrometer (MS) provides high resolution mass information. Multiple dissociation techniques CID, HCD, and optional ETD can be used to enable accurate structural characterization on a UHPLC timescale. Routine analyses have been developed including proteomics analysis, peptide mapping, protein identification, post translational modification site determination.
A traveling wave ion mobility instrument allows routine ion mobility Q-TOF mass spectrometry analysis of biomolecules especially peptide, proteins and protein complexes.
A drift-tube ion mobility-MS platform provides IMS measurements and direct measurement of collision cross sections for analytes including metabolites, lipids, protein and protein complexes.
Its high resolution and high mass capabilities enable the studies of protein and protein complex.
A state-of-the-art instrument enables native IM-mass spectrometry analysis of large protein and protein complexes and protein-ligand interactions.
ILSB Mass Spectrometry
Interdisciplinary Life Sciences Building, Rm 1172
301 Old Main Drive
xueyun.zheng@tamu.edu
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Texas A&M University
College Station, TX 77843
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